Perspectives on the study of neurochemistry and pharmacology of gaming disorder

Summary Relevance Currently, there are no generally accepted approaches to the treatment of gaming disorder, as there is not a single drug registered for this indication. For treatment, psychotherapeutic approaches and pharmacotherapy are used using antidepressants, opioid receptor antagonists, normotimics, NMDA antagonists and antipsychotics. Purpose. Analysis of the perspective of the study of neurochemistry and pharmacology of gaming disorder Analysis results. The dopaminergic and serotonergic systems make the greatest contribution to the functioning of the gambling state. At the same time, the effects of activation of the D3 dopamine receptors, 5-HT 1a, 5-HT2a and 5-HT1b serotonin receptors are of particular interest. For the treatment of gambling addiction in the clinic, it is promising to study the effects of AMPAR antagonists of glutamate receptors. Neuropeptide systems, in particular endogenous opioids, remain poorly understood. The study of neuropeptides ghrelin, orexin, peptides of the neurotrophin, CRF, oxytocin, neuropeptide Y, glucagon-like peptide GLP-1, and kisspeptin also seems to be the most promising. Conclusion. A directed search for peptide targets affecting the mediator systems of the brain can reveal important links for correcting gambling addiction (pathological gambling) and disorders due to addiction to computer games (pathological gaming).