Palladium-Catalyzed Carbonylative Synthesis of Acrylamides from Alkenyl Thianthrenium Salts

Q: What type of study is this?

This is a Experimental Study study.

A Ru‐Han; Jiajun Zhang; Xiao‐Feng Wu

doi:10.1039/d5sc06079f

January 1, 2025Chemical ScienceOpen Access

Palladium-Catalyzed Carbonylative Synthesis of Acrylamides from Alkenyl Thianthrenium Salts

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Key Points

The study highlights an effective palladium-catalyzed method for synthesizing acrylamides.
Findings indicate that using alkenyl thianthrenium salts facilitates this carbonylative synthesis.
This research presents significant implications for the development of covalent drugs in modern therapeutics.
Acrylamide, known for its use as an electrophilic warhead, is central to these therapeutic advances.

Implication

The research demonstrates palladium's role in synthesizing acrylamides, indicating potential therapeutic applications.

Abstract

Covalent drugs have emerged as powerful tools in modern therapeutics, with acrylamide being one of the most widely used electrophilic warheads in recent years. Herein, we report a practical and...

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Cite This Study

Ru‐Han et al. (2025) studied this question.

synapsesocial.com/papers/68f83321d24b29c969481ca2 https://doi.org/10.1039/d5sc06079f

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Palladium-Catalyzed Carbonylative Synthesis of Acrylamides from Alkenyl Thianthrenium Salts

Key Points

Implication

Abstract

Discussion

Cite This Study

Palladium-Catalyzed Carbonylative Synthesis of Acrylamides from Alkenyl Thianthrenium Salts

Key Points

Implication

Abstract

Discussion

Cite This Study

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