Analysis reveals 5% ESBL-E colonization in ICU patients, indicating challenges in detecting resistant strains.
At a United States hospital, sequencing of ICU rectal surveillance cultures indicated 5% ESBL-E colonization. Of confirmed ESBL isolates, 91% were Escherichia coli or Klebsiella pneumoniae; 6% carried non-blaCTX-M genes. Only 53% of third-generation cephalosporin-resistant Enterobacterales harbored ESBL genes, underscoring the limitations of phenotypic approaches as ESBL surrogates, particularly for non-E. coli/K. pneumoniae species.
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Sharara et al. (2025) studied this question.
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