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October 22, 2025JPGN ReportsOpen Access

Toxic megacolon: A rare presentation and novel treatment

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Authors

ADAlyson DavisCenters for Disease Control and Prevention JSJennifer M SchuhChildren's Hospital of Wisconsin JBJanice BitongChildren's Hospital of Wisconsin

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Implication

A case report reveals improved outcomes in a pediatric patient with toxic megacolon following diverting ileostomy, suggesting new treatment alternatives.

Key Points

Pediatric patient with toxic megacolon improved following diverting loop ileostomy and antegrade colonic enemas.
Elimination of Clostridium difficile infection and Hirschsprung disease was confirmed through stool culture and rectal biopsies.
Assessment of colonic motility and anorectal function indicated distal colonic dysmotility alongside chronic constipation and encopresis.
This case supports a novel approach to toxic megacolon management, potentially reducing the need for total abdominal colectomy.

Cite This Study

Davis et al. (2025) studied this question.

synapsesocial.com/papers/68f8a381c0c01e5ef8abdc1a https://doi.org/10.1002/jpr3.70098

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Implication

A case report reveals improved outcomes in a pediatric patient with toxic megacolon following diverting ileostomy, suggesting new treatment alternatives.

Toxic megacolon: A rare presentation and novel treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

Toxic megacolon: A rare presentation and novel treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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