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October 23, 2025Journal of Alzheimer s Disease

Impairment in re-learning of olfactory behaviors in mice expressing intracellular amyloid-β protein oligomers

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Authors

SISaya IwameKIKunio IzuYMYoshihiro Murata

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Overview

Observational analysis reveals impaired olfactory memory in transgenic mice, indicating a model for Alzheimer's disease research.

Key Points

  • Mice with intracellular amyloid-β oligomers exhibited impaired re-learning of odor-reward association.
  • Histological analysis confirmed amyloid-β accumulation in olfactory-related brain regions, particularly in the orbitofrontal cortex.
  • Investigated olfactory behaviors, including odor detection and long-term memory in various age groups of transgenic mice.
  • Findings suggest potential for using transgenic mice in studying early-stage Alzheimer's disease-related olfactory dysfunction.

Cite This Study

Iwame et al. (2025) studied this question.

synapsesocial.com/papers/68f984011881b68f3b7ae4e9https://doi.org/10.1177/13872877251379439
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