Analysis reveals mitochondrial dysfunction affecting acute respiratory distress syndrome, suggesting metabolic alterations contribute to disease severity.
Study Aim Acute respiratory distress syndrome (ARDS) is a critical disease of high mortality. Recent studies have confirmed that metabolic alterations and mitochondrial dysfunction is in involved in the progression of various pulmonary diseases. Moreover, significantly altered metabolite abundances are important in determining the severity of ARDS. Therefore, this study aims to illuminate the pulmonary metabolic profile, investigate the mitochondrial features of ARDS via the integration of metabolomic and transcriptomic analyses, elucidate the pathogenetic mechanism of ARDS.
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Tan et al. (2025) studied this question.
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