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October 23, 2025JAAOS Global Research and ReviewsOpen Access

Impact of Local Vancomycin on Postoperative Outcomes in Ankle Arthrodesis: A Propensity-Matched Cohort Study

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Authors

ACAvani A. ChopraNorthwestern UniversityTJTuckerman JonesRutgers, The State University of New JerseyADAbhiram DawarRutgers, The State University of New Jersey

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Implication

Propensity-matched cohort study reveals local vancomycin reduces nonunion in ankle arthrodesis patients, indicating improved outcomes.

Key Points

  • Local vancomycin administration significantly reduces nonunion risk in ankle arthrodesis patients.
  • Patients in the cefazolin-vancomycin cohort showed a lower nonunion rate of 13% compared to 19% in the cefazolin-only group.
  • Retrospective analysis utilized data from the TriNetX Research Network across 2 decades, identifying significant outcomes.
  • Findings suggest local vancomycin may optimize fusion outcomes in patients undergoing ankle arthrodesis.

Cite This Study

Chopra et al. (2025) studied this question.

synapsesocial.com/papers/68f9bad6d7353cfcfc68f49ehttps://doi.org/10.5435/jaaosglobal-d-25-00320
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