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October 23, 2025PharmaceuticalsOpen Access

Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling

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Authors

RRRaquel N. S. RorizCCClaudia Johana Pérez CardozoGFGabriela Araújo Freire

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Overview

Evaluation shows β-aminohydrazine derivatives improve glucose tolerance in mice, highlighting their insulin sensitivity benefits.

Key Points

  • LASSBio-2129 reduced blood glucose and improved liver glycogen levels in male mice with insulin resistance.
  • The compound enhanced GLUT4 expression while showing favorable ADMET properties and docking efficiency.
  • Assessment included glucose tolerance tests and molecular docking with aldose reductase and glucokinase.
  • Findings support LASSBio-2129 as a potential candidate for treating type 2 diabetes mellitus.

Cite This Study

Roriz et al. (2025) studied this question.

synapsesocial.com/papers/68fa1210f9f8b44535bfcca2https://doi.org/10.3390/ph18101589
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  1. 1The Theoretical Substantiation of the Targeted Search for New DPP4 Inhibitors. Computational Studies of Potential Candidates2024
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  3. 3In Silico Evaluation of Steroidal Alkaloids as Potential Dipeptidyl Peptidase‐4 (DPP‐4) Inhibitors for Type 2 Diabetes Mellitus2026
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