Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 23, 2025National Science ReviewOpen Access

Pan-membrane pyroptosis of liver induced by gasdermin-encoding mRNAs

View Full Paper
Ask AI
Bookmark
Share

Authors

YHYi-Jiao HuangLLLi LinGYGuan Yang

Discussion

Loading...

Member takes

Overview

In vivo pyroptosis induces acute liver damage and systemic inflammation, suggesting potential GSDM-targeted therapeutics.

Key Points

  • Pyroptosis leads to acute liver damage and systemic inflammation due to GSDMDNT expression.
  • Robust expression of GSDMDNT via lipid-nanoparticle injections results in serious effects in mice and primates.
  • Observational analysis shows disulfiram and glucocorticoids can reverse the effects of pyroptosis-induced damage.
  • These findings highlight the potential for developing therapeutics targeting gasdermins in pyroptotic conditions.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68fa1210f9f8b44535bfccc3https://doi.org/10.1093/nsr/nwaf452
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytokine Storm—Definition, Causes, and Implications2022 · 303 citations
  2. 2Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases2017 · 1,649 citations
  3. 3Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites2016 · 115 citations
  4. 4The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity2024 · 80 citations