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October 23, 2025BMC Women s HealthOpen Access

Association between high-density lipoprotein cholesterol-related inflammatory markers and female infertility: a cross-sectional analysis from the National Health and Nutrition Examination Survey (NHANES 2013–2018)

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Authors

SCSiqi CaoMCMeiying CaiHZHaimei Zhang

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Overview

Cross-sectional analysis highlights a significant correlation between high-density lipoprotein cholesterol and infertility risk in reproductive-aged women, suggesting inflammation's role.

Key Points

  • Female infertility is positively associated with high-density lipoprotein cholesterol-related inflammatory markers, indicating a potential risk factor.
  • Adjusted logistic regression showed significant correlations between infertility and inflammatory markers like lymphocyte-high-density lipoprotein ratio.
  • Subgroup analyses revealed notable associations in women aged 35 and younger, and in non-smokers, emphasizing the need for targeted research.
  • Findings underscore the importance of HDL cholesterol levels in understanding infertility risks and the need for further studies to confirm these results.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f742029https://doi.org/10.1186/s12905-025-03917-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association between high‐density lipoprotein‐related inflammation index and female infertility prevalence: Insight from a cross‐sectional study of NHANES2026 · 1 citations
  2. 2Association between high-density lipoprotein-related inflammation index and female infertility in US reproductive-aged women: insights from NHANES 2013–20202025
  3. 3Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility: insights from a cross-sectional study2025 · 1 citations
  4. 4Association between depression and infertility risk among American women aged 18–45 years: the mediating effect of the NHHR2024 · 11 citations
  5. 5Association between the serum uric acid-to-HDL-cholesterol ratio and female infertility: The mediating role of BMI2026