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October 23, 2025Orphanet Journal of Rare DiseasesOpen Access

Comparison of intravenous efgartigimod and intravenous immunoglobulin in patients with Guillain–Barré syndrome

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Authors

HZHuiqiu ZhangHarbin University of Science and TechnologyFZF. Y. ZhaiHenan Institute of Science and TechnologyMSMenghan SuShanxi Medical University

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Implication

Retrospective analysis compares efgartigimod and IVIg in Guillain–Barré syndrome, suggesting potential benefits of efgartigimod.

Key Points

  • Primary outcome of GBS Disability Scale score ≤ 2 was not achieved, with an odds ratio of 0.67.
  • Secondary outcomes showed improvement in MRC sum score for efgartigimod with P = 0.007, highlighting its effectiveness.
  • Intravenous immunoglobulin and efgartigimod were assessed in adult patients with Guillain–Barré syndrome via a retrospective study.
  • Efgartigimod was superior in exploring neurofilament light chain levels, indicating its potential role in GBS management.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f74204ehttps://doi.org/10.1186/s13023-025-04060-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamics and prognostic value of serum neurofilament light chain in Guillain-Barré syndrome2024 · 40 citations
  2. 2Evaluation of Pharmacists' Work in a Physician‐Pharmacist Collaborative Model for the Management of Hypertension2016 · 79 citations
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  4. 4Update on Intravenous Immunoglobulin in Neurology: Modulating Neuro-autoimmunity, Evolving Factors on Efficacy and Dosing and Challenges on Stopping Chronic IVIg Therapy2021 · 105 citations
  5. 5Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis2011 · 967 citations