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October 23, 2025Scientific ReportsOpen Access

Bioinformatics analyses of comorbid mechanisms between psoriasis and type 2 diabetes mellitus

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Authors

ZWZhimin WangJMJing Long MuYZYiwen Zhang

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Overview

Bioinformatics reveals altered cytokine receptor interactions and common pathophysiology in psoriasis and T2DM.

Key Points

  • Significant co-DEGs identified link psoriasis and type 2 diabetes mellitus, indicating shared pathophysiology.
  • Gene Set Enrichment Analysis showed critical pathways involving cytokine receptor interactions in both diseases.
  • Observational analysis across microarray expression profiles from Gene Expression Omnibus and various datasets facilitated discovery.
  • Findings highlight the role of immune cell infiltration in the pathogenesis of skin and metabolic diseases.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f742156https://doi.org/10.1038/s41598-025-20762-8
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