What type of study is this?

This is a Quantitative Study study (also classified as: Experimental Study).

October 23, 2025Clinical ProteomicsOpen Access

Identification of adrenocorticotropic hormone–specific therapeutic biomarkers in infantile epileptic spasm syndrome using data-independent acquisition mass spectrometry

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This analysis uncovers therapeutic biomarkers related to ACTH efficacy in IESS patients, suggesting potential interventions.

Infantile epileptic spasm syndrome therapeutic response varies due to underlying molecular factors, emphasizing the need for specific biomarkers.
Eighty-four proteins were analyzed, identifying Haptoglobin and Aldolase A as important diagnostic biomarkers with significant predictive potential.
Data-independent acquisition mass spectrometry was utilized alongside targeted ELISA validation to ensure robust findings regarding protein levels.
These insights into IESS pathogenesis may refine therapeutic strategies in managing treatment response variables associated with ACTH.

Zou et al. (2025) studied this question.

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