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October 23, 2025Future Oncology

PERI-START: a phase II trial of perioperative TACE, tislelizumab, and lenvatinib in early-stage hepatocellular carcinoma

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Authors

DKDiao KongYTYujuan TangYZYongjie Zhou

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Overview

Phase II trial shows major pathological response in resectable HCC using TACE and lenvatinib, indicating potential for perioperative therapies.

Key Points

  • Major pathological response achieved in patients with high-risk hepatocellular carcinoma using TACE and lenvatinib.
  • Primary endpoint focused on major pathological response rate of the treatment strategy applied.
  • Trial assessed both neoadjuvant and adjuvant administration of therapies in a single arm setup.
  • Results may highlight new pathways for improving outcomes in early-stage liver cancer post-surgery.

Cite This Study

Kong et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f742256https://doi.org/10.1080/14796694.2025.2577625
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neoadjuvant tislelizumab combined with lenvatinib plus transcatheter arterial chemoembolization in resectable hepatocellular carcinoma with high-risk of recurrence: A prospective, single-arm, phase II trial.2024
  2. 2TACE plus lenvatinib and tislelizumab for intermediate-stage hepatocellular carcinoma beyond up-to-11 criteria: a multicenter cohort study2024 · 14 citations
  3. 3TACE combined with tislelizumab and lenvatinib in the treatment of advanced liver cancer: A real world study.2024
  4. 4TACE combined with tislelizumab and lenvatinib in the treatment of intermediate-to-advanced hepatocellular carcinoma: a retrospective real-world study2026
  5. 5Efficacy and safety of TACE plus lenvatinib with PD-1 inhibitor for unresectable huge hepatocellular carcinoma: a multicenter retrospective cohort study2025 · 8 citations