March 1, 2023Cancer Research
Abstract GS1-01: Race and clinical outcomes in the RxPONDER Trial (SWOG S1007)
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Discussion
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Implication
Randomized trial reveals worse survival in Black women with hormone receptor-positive breast cancer despite equivalent recurrence scores, highlighting critical disparities.
Key Points
- Invasive disease-free survival was significantly lower in Black women with hormone receptor positive breast cancer, even though recurrence score distributions were equivalent across cohorts.
- Invasive disease-free survival reached 87.0% for Black participants compared with 91.5% for White participants, persisting after multivariable adjustment for assigned treatment.
- Analysis of trial records across 4,048 women highlights that Black patients had worse distant relapse-free survival and higher tumor grade, calling for novel therapeutic strategies.
Cite This Study
Abdou et al. (2023) studied this question.