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October 27, 2025Macromolecular BioscienceOpen Access

A pH‐Responsive Polycarbonate Nanoplatform for Synergistic Chemodynamic/Chemotherapy via Cinnamaldehyde Prodrug‐Enhanced Fe 3+ ‐Mediated Fenton‐Like Reaction

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Authors

WWWei WangJLJinghang LiYDYaodong Di

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Overview

Nanoplatform improves hydroxyl radicals and doxorubicin delivery in cancer cells, indicating potential for enhanced therapy.

Key Points

  • Doxorubicin increased reactive oxygen species in cancer cells, improving therapeutic effects against tumors.
  • Nanoplatform strategy combined pH-responsive polycarbonate with enhanced Fenton-like reaction for CDT.
  • Increased hydrogen peroxide levels led to greater hydroxyl radical generation in the tumor microenvironment.
  • Study highlights dual-action approach to overcoming limitations in tumor microenvironment and boosting efficacy.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68ff87d8c8c50a61f2bdca8ahttps://doi.org/10.1002/mabi.202500354
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