Strong inhibition of IL-6 signal is clinically and serologically effective in refractory adult-onset Still’s disease

Journal Article Accepted manuscript Strong inhibition of IL-6 signal is clinically and serologically effective in refractory adult-onset Still's disease Get access Koji Suzuki, Koji Suzuki Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan https://orcid.org/0000-0003-1358-7069 Search for other works by this author on: Oxford Academic PubMed Google Scholar Hideto Kameda, Hideto Kameda Division of Rheumatology, Department of Internal Medicine, Toho University, Tokyo, Japan https://orcid.org/0000-0002-4330-5782 Search for other works by this author on: Oxford Academic PubMed Google Scholar Kei Ikeda, Kei Ikeda Department of Rheumatology, Dokkyo Medical University, Mibu, JapanDepartment of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan https://orcid.org/0000-0003-0574-9611 Search for other works by this author on: Oxford Academic PubMed Google Scholar Tomonori Ishii, Tomonori Ishii Department of Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan https://orcid.org/0000-0001-5361-5824 Search for other works by this author on: Oxford Academic PubMed Google Scholar Kosaku Murakami, Kosaku Murakami Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan https://orcid.org/0000-0001-5981-4648 Search for other works by this author on: Oxford Academic PubMed Google Scholar Hyota Takamatsu, Hyota Takamatsu Department of Clinical Research Center for Autoimmune Diseases, National Hospital Organization, Osaka Minami Medical Center, Osaka, JapanDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan https://orcid.org/0000-0002-0382-5142 Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshiya Tanaka, Yoshiya Tanaka Department of Molecular Targeted Therapeutics, University of Occupational and Environmental Health, Kitakyushu, Japan https://orcid.org/0000-0002-0807-7139 Search for other works by this author on: Oxford Academic PubMed Google Scholar Takayuki Abe, Takayuki Abe Faculty of Data Science, Kyoto Women's University, Kyoto, Japan https://orcid.org/0009-0003-5442-7034 Search for other works by this author on: Oxford Academic PubMed Google Scholar Tsutomu Takeuchi, Tsutomu Takeuchi Division of Rheumatology, Keio University School of Medicine, Tokyo, JapanSaitama Medical University, Saitama, Japan https://orcid.org/0000-0003-1111-8218 Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuko Kaneko Yuko Kaneko Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan Correspondence: Yuko Kaneko, MD, PhD, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan, TEL: +81-3-5363-3786 FAX: +81-3-5379-5037 Email: [email protected] https://orcid.org/0000-0003-2646-5765 Search for other works by this author on: Oxford Academic PubMed Google Scholar Rheumatology, keaf562, https://doi.org/10.1093/rheumatology/keaf562 Published: 25 October 2025 Article history Received: 07 October 2025 Revision received: 13 October 2025 Accepted: 15 October 2025 Published: 25 October 2025