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This is a Quantitative Study study.

October 27, 2025PharmaceuticalsOpen Access

A Novel Workflow for Non-Animal PBK Modelling of UV Filters: Oxybenzone as a Case Study

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Novel workflow improves systemic exposure estimates of UV filters in nonanimal assessments, suggesting refined absorption kinetics and analysis.

Improved estimates of systemic exposure for UV filters were achieved through a novel PBK modelling workflow, enhancing safety assessments.
Sensitivity and uncertainty analyses revealed variable reliability across input parameters in the PBK model for UV filters.
The TCAT model accurately simulated absorption kinetics for oxybenzone formulations, correlating closely with clinical data.
Formulation-dependent differences in absorption were noted, though clinical variability may be influenced by subject demographics.

Golbamaki et al. (2025) studied this question.

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October 27, 2025PharmaceuticalsOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Novel workflow improves systemic exposure estimates of UV filters in nonanimal assessments, suggesting refined absorption kinetics and analysis.

Improved estimates of systemic exposure for UV filters were achieved through a novel PBK modelling workflow, enhancing safety assessments.
Sensitivity and uncertainty analyses revealed variable reliability across input parameters in the PBK model for UV filters.
The TCAT model accurately simulated absorption kinetics for oxybenzone formulations, correlating closely with clinical data.
Formulation-dependent differences in absorption were noted, though clinical variability may be influenced by subject demographics.

Golbamaki et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark