Treatment, Intervention and Improvement of Psychosocial Adaptation in Patients with Chronic Urticaria Empirical Evidence from China

Objective: This study aimed to evaluate the effectiveness of a comprehensive intervention in improving biological indicators and psychosocial adaptation in patients with chronic urticaria. Methods: One hundred patients with chronic urticaria were randomly assigned to an experimental group and a control group. All patients received standard physiological interventions, while the experimental group underwent and assessed standardized psychosocial support measures. Key outcomes included serum IgE and high-sensitivity C-reactive protein (hs-CRP) levels, as well as psychosocial adaptation assessed using the PASQ scale. Results: After two months of follow-up, the experimental group showed a significant reduction in post-treatment IgE levels to (30.95 ± 5.77) IU/mL, significantly lower than the control group's (43.42 ± 5.94) IU/mL (t = 9.71, p = 0.001). Similarly, the experimental group's hs-CRP levels also decreased significantly to (9.62 ± 2.13) mg/L, lower than the control group's (12.12 ± 2.38) mg/L (t = 5.04, p = 0.001). Psychosocial function evaluations revealed that the experimental group scored significantly higher than the control group in emotional dimension (37.84 ± 2.48), self-perception dimension (28.40 ± 1.62), and social dimension (18.92 ± 1.18) after treatment (p <0.001). Conclusion: This intervention demonstrated significantly better outcomes than conventional approaches in regulating allergic immune responses, managing systemic inflammation, and enhancing psychosocial resilience among patients with chronic urticaria. These findings underscore the value of implementing comprehensive strategies in chronic urticaria management, highlighting the critical importance of integrating biological, psychological, and social dimensions in therapeutic approaches.