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November 9, 2024Journal of Research in PharmacyOpen Access

Assessing the gastroprotective effects of pioglitazone by determining its effect on TNF-α and SOD levels on indomethacin-induced gastric ulcer in a rat model

Hela Muayed Abd-Alqhani Huda I. Al–Qadhi

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Key Points

Pioglitazone showed significant improvements in TNF-α and SOD levels, reducing gastric ulcer severity in rats.
Histological examination confirmed decreased lesions and damage scores in treated rats compared to controls.
The positive control group received indomethacin 60 mg/kg to induce gastric ulcers for comparison.
Antioxidant and inflammatory marker levels indicate pioglitazone's protective role against indomethacin-induced gastric damage.

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Implication

Observational analysis assessed pioglitazone's effect on TNF-α and SOD in gastric ulcers, suggesting potential benefits for treatment plans.

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Cite This Study

Abd-Alqhani et al. (2024) studied this question.

synapsesocial.com/papers/68ff87f1c8c50a61f2bdd78f https://doi.org/10.12991/jrespharm.1798118

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