Synthesis, Physicochemical Analysis and Pharmacological Activity of Some Coumarin Derivatives

The antihypoxic activity of known coumarin derivatives, new synthesized pharmaceutical substances (PS) and the antihypoxant ethylmethylhydroxypyridine succinate was studied in vivo in various models of acute hypoxia. The most pronounced antihypoxic effect, determined by the survival time of mice in seconds under acute hemic hypoxia, was observed by the substances obtusifol (971,9±158,1 s), PS№4 (1020,0±309,2 s) and №5 (1031,2±188,9 s); under acute histotoxic hypoxia – obtusifol (548,9±110,6 s) and umbelliferone (601,2±113,7 s); under acute normobaric hypoxia with hypercapnia – PS№4 and umbelliferone (2290,0±781,2 s).