Ampicillin shows activity against Gram-negative bacilli, indicating its effectiveness despite penicillinase resistance.
As frequently noted in both the medical literature and the lay press, a variety of penicillin derivatives can now be produced semi-synthetically, thus making it possible to “build in” such desirable properties as resistance to penicillinase. Ampicillin (Penbritin - Beecham) is the first penicillin with useful activity against Gram-negative bacilli.
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