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February 1, 1974CancerOpen Access

Small cell carcinoma of the lung: Staging, paraneoplastic syndromes, treatment, and survival

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Authors

RERobert T. EaganLML. Herbert MaurerRFR. Jackson Forcier

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Overview

Randomized trial evaluates treatment response and survival in patients with small cell carcinoma, indicating improved outcomes with combined therapy.

Key Points

  • Patients with small cell carcinoma showed an objective response of 88% when treated with cyclophosphamide and vincristine, enhancing treatment efficacy.
  • Of the 37 patients analyzed, 55% had a complete response to combined chemotherapy and radiation therapy, highlighting treatment effectiveness.
  • Assessment prior to therapy indicated 84% had extensive disease with 14% experiencing CNS metastases, underscoring disease severity before treatment initiation.  Even with treatment, 21% relapsed in the CNS, indicating potential challenges in disease management after therapy recovery. 

Cite This Study

Eagan et al. (1974) studied this question.

synapsesocial.com/papers/69029bc2f49c13ca528a96d2https://doi.org/10.1002/1097-0142(197402)33:2<527::aid-cncr2820330230>3.0.co;2-r
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Survival of Patients with Inoperable Lung Cancer: A Large-Scale Randomized Study of Radiation Therapy Versus Placebo1968 · 291 citations
  2. 2Oat cell carcinoma of the lung:A review of 138 cases1969 · 150 citations