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This is a Experimental Study study.

November 1, 2025Open Access

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.

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Chronic exposure to oxidized phospholipids activates NLRP3 and IL-1β in atherosclerosis, indicating a novel pathway for disease progression.

Bioactive interleukin production activates NLRP3 in atherosclerosis, highlighting a critical inflammatory pathway.
Chronic sensing of oxidized lipids potentially explains NLRP3 activation in non-communicable diseases.
Ex vivo analyses reveal a crucial role of NRF2 and mitochondrial DNA in NLRP3 activation within macrophages.
These insights emphasize the importance of host-derived signals in sustaining atherogenesis.

Dufies et al. (2025) studied this question.

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Chronic exposure to oxidized phospholipids activates NLRP3 and IL-1β in atherosclerosis, indicating a novel pathway for disease progression.