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November 1, 2025Journal of International Medical ResearchOpen Access

Short- and long-term effects of single neonatal exposure to propofol anesthesia on cognitive function

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Authors

SLShilei LiuMFMin FengSZShan Zheng

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Overview

Observational analysis reveals no impact of single neonatal propofol exposure on cognitive function in mice, suggesting safety for use in early life.

Key Points

  • Neonatal exposure to propofol anesthesia showed no impairment of cognitive function over time.
  • No significant differences were found in recognition index or memory tests conducted at various intervals.
  • Histopathology and synaptic function analysis confirmed no abnormalities in hippocampal structures or protein levels.
  • Findings imply that single exposure to propofol in newborns may not have detrimental cognitive effects.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/69054ffa1a99e50463de6780https://doi.org/10.1177/03000605251389799
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