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November 1, 2025Open Access

Economic and Humanistic Burden of Multimorbidity in the United States: A Longitudinal Study of Expenditure and Quality of Life Trajectories, 2019–2022

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Authors

IAIbrahim AlliuSTSubash ThapaLYLili Yu

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Overview

Longitudinal study finds multimorbidity raises out-of-pocket costs and lowers quality of life, suggesting a need for chronic disease prevention.

Key Points

  • Quality of life consistently declined over several years, emphasizing the humanistic toll of chronic conditions.
  • Mean out-of-pocket costs increased significantly, reflecting the substantial economic burden of multimorbidity in adults.
  • Analysis of Medical Expenditure Panel Survey data allowed for weighted estimations of national expenditure trends.
  • Policies promoting integrated care models are necessary to improve health equity in managing multimorbidity.

Cite This Study

Alliu et al. (2025) studied this question.

synapsesocial.com/papers/69054ffa1a99e50463de68d2https://doi.org/10.20944/preprints202510.2135.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multimorbidity and health related quality of life in U.S. adults: A population-based study2026
  2. 2Quantifying cost and health-related quality of life outcomes in different multimorbidity trajectories: a systematic review protocol2025
  3. 3Life-Stage Differences in the Longitudinal Associations of Multimorbidity Profiles with Economic Burden, Health-Related Quality of Life, and Inpatient Utilization2026
  4. 4The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries2024 · 14 citations
  5. 5Impact of multimorbidity on change in quality of life in a multi-ethnic Asian population: a longitudinal study2026