Answers are grounded in this paper and cite their sources.
Asymmetric nickel-catalyzed cycloadditions generate imidazolidines with up to 97% ee in aziridines and imines, indicating potential for enantioconvergent synthesis.
We report asymmetric nickel-catalyzed cycloadditions of aziridines and imines enabled by a newly designed tyrosine-derived FOXAP ligand, delivering up to 97% ee and >20:1 dr. The reaction constructs imidazolidines bearing two nonadjacent stereocenters from racemic vinylaziridines and achiral imines in an enantioconvergent manner.
No takes yet. Share an insight, caveat, or question.
Takahashi et al. (2025) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: