Analysis reveals enantioconvergent carbamoylation of aziridines, highlighting a new approach to produce β-amino amides.
Herein, we disclose an enantioconvergent carbamoylation of racemic aziridines enabled by a dual catalytic strategy. The method offers a new entry point to highly enantioenriched β-amino amides from simple precursors and is characterized by its broad applicability, even with challenging combinations. Preliminary studies with well-defined nickel complexes support a scenario via carbamoyl organometallic intermediates.
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Zhang et al. (2025) studied this question.
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