Comment on: The Healing Power of Amniotic Membrane Extract Eye Drops

This correspondence comments on the case report by Vargas Lopez et al., describing the successful use of amniotic membrane extract eye drops (AMEED) in preventing ocular perforation in a centenarian patient. The case highlights AMEED’s role as a non-invasive therapy that delivers regenerative cytokines and growth factors to the ocular surface. Emerging prospective and real-world studies show high success rates in refractory corneal ulcers, neurotrophic disease, and severe dry eye. The preclinical models confirm better outcomes compared with amniotic membrane transplantation, while immunological studies support anti-inflammatory and pro-regenerative mechanisms. We emphasise that AMEED should be considered beyond anecdotal rescue therapy, with further trials needed to define dosing, efficacy, and how it can be integrated into corneal ulcer management.