Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 4, 2025Open Access

Physical mechanisms of nanoparticle-membrane interactions: A coarse-grained study

View Full Paper
Ask AI
Bookmark
Share

Authors

MPMassimiliano PaesaniIIIoana M. Ilie

Discussion

Loading...

Member takes

Overview

Coarse-grained simulations reveal how nanoparticle topology impacts endocytosis in targeted therapies.

Key Points

  • Endocytosis efficiency increases with optimal nanoparticle topology and surface properties, enhancing drug delivery.
  • Significant findings include distinct interaction regimes based on adhesion strength and nanoparticle characteristics.
  • Investigative approach utilized coarse-grained simulations of flexible nanoparticle interactions with a lipid bilayer.
  • This framework suggests design principles for soft nanocarriers to improve cellular membrane uptake.

Cite This Study

Paesani et al. (2025) studied this question.

synapsesocial.com/papers/690945348f2297dc13532f10https://doi.org/10.1101/2025.10.31.685850
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems2012 · 3,880 citations
  2. 2Flexible Nanoparticles Reach Sterically Obscured Endothelial Targets Inaccessible to Rigid Nanoparticles2018 · 104 citations
  3. 3Tunable generic model for fluid bilayer membranes2005 · 406 citations
  4. 4Clustering and separation of hydrophobic nanoparticles in lipid bilayer explained by membrane mechanics2018 · 35 citations
  5. 5Mechanisms of Budding of Nanoscale Particles through Lipid Bilayers2012 · 56 citations