This review highlights how extracellular matrix properties affect immune cells and immunotherapy resistance in cancer, suggesting new strategies for treatment.
Key Points
Immunotherapy may enhance effectiveness by targeting extracellular matrix properties in cancer treatment.
Evidence shows that the structure of the extracellular matrix can limit immune cell infiltration and effectiveness.
This review utilizes insights from current literature on tumor microenvironment and immune interactions.
Potential strategies can arise from understanding the crosstalk between extracellular matrix and immune evasion pathways.