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June 20, 2026Current Cancer Drug Targets

Targeting the Tumor Extracellular Matrix: A New Frontier in CancerTherapy

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Authors

AGAnjana GoelISIstuti SaraswatSPSwadha Pandey

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Overview

This review explores ECM-targeting strategies to improve cancer treatments, indicating promising outcomes for aggressive tumors.

Key Points

  • The aim is to evaluate new cancer therapies targeting the extracellular matrix (ECM) to improve treatment efficacy.
  • Review of existing literature on ECM-targeting strategies in cancer therapy.
  • Discussion of ECM remodeling and its role in cancer progression.
  • Examination of various therapeutic approaches including enzyme activity inhibition and drug delivery systems.
  • Targeting ECM abnormalities can enhance treatment effectiveness in stroma-rich cancers.
  • Strategies like normalizing ECM and reprogramming cancer-associated fibroblasts show potential.
  • Combination therapies improve immune responses against cancer.

Cite This Study

Goel et al. (2026) studied this question.

synapsesocial.com/papers/6a363172db0793dc1a53858chttps://doi.org/10.2174/0115680096456643260604051613
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4275: Targeting tumor extracellular matrix to improve response to therapy2024
  2. 2Strategies for Efficient Targeting of Tumor Collagen for Cancer Therapy2022 · 46 citations
  3. 3The extracellular matrix in inflammation and cancer2026 · 14 citations
  4. 4Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment2024 · 52 citations
  5. 5Biophysical Properties of the Extracellular Matrix in Cancer: Insights Into Immunotherapy2025 · 3 citations