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November 9, 2025Open Access

Dysregulation of U12-Type Splicing in Lupus Neutrophils

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Authors

LBLuz P. BlancoBRBinod RegmiCCCarmelo Carmona‐Rivera

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Overview

Analysis reveals neutrophil dysfunction and exon skipping in systemic lupus erythematosus, suggesting minor spliceosome involvement in immune regulation.

Key Points

  • Impaired neutrophil function contributes to disease activity and immune regulation in systemic lupus erythematosus.
  • Specifically, exon skipping was observed in genes relating to neutrophil biology, highlighting dysfunction.
  • Observational analysis of neutrophil subsets demonstrated U12-type splicing defects correlated with disease severity.
  • These findings underscore the role of the minor spliceosome in contributing to the pathogenesis of lupus.

Cite This Study

Blanco et al. (2025) studied this question.

synapsesocial.com/papers/690fdcdaf60c54d04ea38087https://doi.org/10.1101/2025.11.06.686965
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