A remarkable span of frontier astrophysics, from gravitational-wave archaeology to the origin of the elements to interpreting snapshots of the earliest galaxies, depends sensitively on our understanding of massive star formation and evolution in near-pristine, relatively enriched gas. From the surprisingly massive black holes detected by LIGO/Virgo to highly ionized nebulae with peculiar enrichment patterns observed in galaxies at Cosmic Dawn, evidence is mounting that our understanding of massive-star populations at very low metallicity remains critically incomplete. The fundamental limitation is the hand nature has dealt us: only a few star-forming galaxies within 1 Mpc can currently be resolved into individual stars, and none reach the extreme metallicities and star-formation intensities that characterized the early Universe. With an ultraviolet integral-field spectrograph aboard the Habitable Worlds Observatory (HWO), this barrier will finally be broken. HWO will bring rare, actively star-forming, extremely metal-poor dwarf galaxies at 10-20 Mpc such as I Zw 18 within reach of resolved UV-optical spectroscopy, providing our first direct, statistical view of individual massive stars and the feedback they drive at >30 M_ and <10% Z_. This science is deeply synergistic with many next-generation facilities, yet requires the unique combination of spatial resolution and UV/optical sensitivity that only HWO can provide. The massive star science enabled by HWO within the Local Volume represents a transformational advance in our ability to probe the earliest stellar populations - those that seeded the Milky Way and other galaxies with the first heavy elements, and paved the way for life in the transparent, reionized Universe we inhabit today.
Senchyna et al. (Wed,) studied this question.