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November 9, 2025International Journal For Multidisciplinary ResearchOpen Access

Evaluation of Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Type 2 Diabetes Mellitus Using Spectral-Domain Optical Coherence Tomography

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Authors

KBKavya BansalTMTanisha MittalRARajesh Aggarwal

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Overview

Cross-sectional study reveals negative correlation of retinal thickness with diabetes duration and HbA1c in type 2 diabetes, indicating potential neurodegenerative biomarker.

Key Points

  • Significant thinning of retinal nerve fiber and ganglion cell layers occurs in type 2 diabetes.
  • Average pRNFL thickness was 90.6 µm in patients without retinopathy, and 86.2 µm with mild retinopathy.
  • Cross-sectional study using spectral-domain optical coherence tomography measured retinal thickness across groups.
  • Findings highlight SD-OCT's role as a biomarker for preclinical retinal neurodegeneration, supporting early intervention.

Cite This Study

Bansal et al. (2025) studied this question.

synapsesocial.com/papers/690fdce2f60c54d04ea3847ehttps://doi.org/10.36948/ijfmr.2025.v07i06.59091
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The silent neurodegeneration in diabetic retina: Cross-sectional analysis and comparison of spectral-domain optical coherence tomography-based ganglion cell–inner plexiform layer thickness and inner retinal layers thickness2026
  2. 2A comparison of macular ganglion cell complex thickness in diabetic patients with and without diabetic retinopathy using SD-OCT2024
  3. 3Retinal Fiber Layer and Macular Ganglion Cell Layer Thickness in Diabetic Patients2019 · 3 citations
  4. 4Changes in Retinal Ganglion Cell (RGC) and Retinal Nerve Fiber Layer (RNFL) Thickness in Children with Type 1 Diabetes Mellitus at Dr. M. Djamil General Hospital, Padang, Indonesia2024
  5. 5Evaluation of thickness of individual macular retinal layers in diabetic eyes from optical coherence tomography2024 · 5 citations