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May 16, 2022Journal of Cystic FibrosisOpen Access

Dose adjustments of Elexacaftor/Tezacaftor/Ivacaftor in response to mental health side effects in adults with cystic fibrosis

Giulia Spoletini L. Gillgrass K. Pollard N. Shaw E. Williams C. Etherington I. Clifton D. Peckham

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Abstract

Dose adjustment of ELX/TEZ/IVA was associated with improvement in mental health AEs without significant clinical deterioration. Sweat chloride concentration may prove useful as a surrogate marker of CFTR function.

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Spoletini et al. (2022) studied this question.

synapsesocial.com/papers/6917e8612bb051071b682b73 https://doi.org/10.1016/j.jcf.2022.05.001

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