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November 21, 2025DiagnosticsOpen Access

Quantitative CT Perfusion and Radiomics Reveal Complementary Markers of Treatment Response in HCC Patients Undergoing TACE

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Authors

NFNicolas FezoulidisJSJakob SlavicekJNJulian Niklas Nonninger

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Overview

Retrospective analysis shows changes in perfusion and radiomic features in HCC patients post TACE, suggesting improved treatment assessment for precision oncology.

Key Points

  • This research aims to evaluate the changes in CT perfusion parameters and radiomic features in HCC patients during TACE treatment.
  • Retrospective analysis of 32 patients with HCC
  • Assessment of computed tomography perfusion and radiomic analysis before and after TACE
  • Statistical comparisons using Wilcoxon signed-rank test and Spearman’s correlation
  • Extraction under Image Biomarker Standardization Initiative guidelines
  • Arterial flow decreased significantly after TACE (p = 0.009)
  • Radiomic features demonstrated significant changes, especially in tumors ≥50 mm in diameter
  • AUC of 0.87 achieved in a multivariable logistic regression model for predictive biomarker potential

Cite This Study

Fezoulidis et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ecc0ce034ddc34ed04https://doi.org/10.3390/diagnostics15232952
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