Cytokine dynamics influence inflammation and drive therapeutic strategies in periodontal disease, suggesting new treatment pathways.
Members of the IL-12 cytokine family exert both pathogenic and protective influences in periodontal disease. Therapeutic strategies that suppress IL-12/IL-23-driven inflammation while augmenting IL-27/IL-35-mediated regulation show promise as host-modulatory approaches in periodontal treatment. A deeper understanding of these immunologic dynamics may advance precision-based periodontal therapies.
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Wang et al. (2025) studied this question.
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