Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 2001ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue

View Full Paper
Ask AI
Bookmark
Share

Authors

DLDavid F. LappinUniversity of GlasgowCMCalum MacLeodPharmaron (United Kingdom)AKA. KerrStanford Health Care

Discussion

Loading...

Member takes

Overview

Tissue analysis reveals predominant Th2 and anti-inflammatory IL-10 expression in periodontitis lesions, suggesting active local immune down-regulation.

Key Points

  • Investigate the relative abundance and functional distribution of Th1, Th2, proinflammatory, and anti-inflammatory cytokines within periodontitis granulation tissue.
  • Examined biopsied granulation tissue from 10 patients with early onset periodontitis and 10 patients with adult periodontitis, utilizing matched gingival tissue sections as controls.
  • Identified cells expressing IL-2, IL-4, IL-6, IL-10, IL-15, TNF-alpha, and IFN-gamma protein and mRNA transcripts using polyclonal monospecific antibodies and oligonucleotide probes.
  • Cells expressing Th2 cytokines (IL-4 and IL-6) were more numerous than cells expressing Th1 cytokines (IL-2 and IFN-gamma) in both early onset and adult periodontitis tissues.
  • IL-15-positive cells outnumbered IL-2-positive cells, indicating an alternative pattern of T cell immune regulation in periodontal lesions.
  • Leukocytes expressing the anti-inflammatory cytokine IL-10 were significantly more widely distributed than those expressing proinflammatory cytokines IL-6 and TNF-alpha.

Cite This Study

Lappin et al. (2001) studied this question.

synapsesocial.com/papers/69dbeacef7e0c66ced836dd7https://doi.org/10.1046/j.1365-2249.2001.01448.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for the stochastic acquisition of cytokine profile by CD4<sup>+</sup> T cells activated in a T helper type 2‐like response <i>in vivo</i>1995 · 94 citations
  2. 2IL-10 inhibits cytokine production by activated macrophages1991 · 2,921 citations
  3. 3Humoral immune responses in periodontal disease may have mucosal and systemic immune features1999 · 70 citations
  4. 4Cytokine Profiles of Cells Extracted from Humans with Periodontal Diseases1998 · 131 citations