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November 21, 2025Medical Principles and PracticeOpen Access

Oral Manifestations in Children with Celiac Disease- Part II: Salivary Changes, Immunological Markers and their Correlation with Oral Health Status

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Authors

SASibel AcarGAGuzide AksuEHElif Esin Hameş

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Overview

Cross-sectional analysis reveals correlations between immune markers and oral health in children with celiac disease, highlighting significant oral health disadvantages.

Key Points

  • This research aims to explore the relationship between salivary immune markers and oral health issues in children with celiac disease.
  • Cross-sectional study involving 128 children: 97 with celiac disease and 31 healthy controls.
  • Participants underwent oral examinations for dental defects, caries, and oral lesions.
  • Saliva samples were analyzed for flow rate, buffer capacity, pH, and specific immune markers.
  • Higher prevalence of dental enamel defects and recurrent aphthous stomatitis in children with celiac disease compared to controls.
  • Positive correlation between serum tTG IgA and salivary tTG IgA levels.
  • Significant link found between enamel defects and salivary levels of tTG IgA.

Cite This Study

Acar et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ecc0ce034ddc34eebbhttps://doi.org/10.1159/000549623
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral manifestations on children with celiac disease: Gluten consumption as causative factor2025
  2. 2Assessment of salivary microbiota profile as a potential diagnostic tool for pediatric celiac disease2024 · 2 citations
  3. 3Relative risk of oral manifestations with celiac disease: a systematic review and meta-analysis2026 · 1 citations
  4. 4Examine the Relationship between DMFT Index, Enamel Defects, and Oral Health-Related Quality of Life in Children with Celiac Disease2024
  5. 5Association of oral manifestations with celiac disease in Syrian patients: A case-control study2025