Randomized trial shows dexmedetomidine reduces postoperative delirium in elderly patients undergoing radical mastectomy, indicating a dose-dependent effect.
The DEX effect in POD down-regulation is dose-dependent. DEX (0.8 μg/kg) effectively reduces POD incidence in elderly patients undergoing radical mastectomy for breast cancer by inhibiting the production of pro-inflammatory cytokines. Registry: Chinese Clinical Trial Registry, ChiCTR2500101907. Registration date: 6th, May, 2025.
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Qiang et al. (2025) studied this question.
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