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November 21, 2025npj Genomic MedicineOpen Access

Transferability of polygenic risk scores for metabolic and cardiovascular traits in an underrepresented population

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Authors

PPPhongthana PasookhushASApinya SurawitSSSophida Suta

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Overview

Cross-sectional and longitudinal analyses show polygenic risk scores predict type 2 diabetes and cardiovascular disease risk in Thai individuals, suggesting varying effectiveness across traits.

Key Points

  • The aim was to evaluate the performance of polygenic risk scores for metabolic and cardiovascular traits in a Thai population.
  • Evaluated 64 published polygenic risk scores for eight traits in 4879 Thai individuals.
  • Used imputed SNP-array data for analysis.
  • Conducted cross-sectional and six-year longitudinal analyses.
  • Polygenic risk scores for type 2 diabetes and lipid traits showed significant predictive utility.
  • LDL-C and TC scores explained up to 9.8% and 7.8% of variance, respectively.
  • The T2D polygenic risk score achieved an area under the curve of 0.70.
  • Some cardiovascular disease polygenic risk scores had an inverse association with disease risk.

Cite This Study

Pasookhush et al. (2025) studied this question.

synapsesocial.com/papers/6924e3f8c0ce034ddc34f3bfhttps://doi.org/10.1038/s41525-025-00532-1
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Also Consider

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