What question did this study set out to answer?

This study aims to identify the maternal metabolomic signatures associated with prenatal heat exposure and preterm birth.

November 21, 2025Science AdvancesOpen Access

Critical windows of prenatal heat exposure and preterm birth: Metabolomic study in the Atlanta African American Maternal-Child Cohort

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Authors

KTKaitlin R. Taibl PBPriyanka A Bhanushali ADAnne L. Dunlop

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Implication

Prospective analysis identified metabolic pathways related to heat exposure and preterm birth, implying environmental risks may alter biological processes.

Key Points

This study aims to identify the maternal metabolomic signatures associated with prenatal heat exposure and preterm birth.
Prospective analysis involving 215 participants from the Atlanta African American Maternal-Child Cohort.
Collected serum samples underwent untargeted metabolomic profiling during early and late pregnancy.
Daily maximum ambient temperature was averaged over three defined exposure windows.
Conducted metabolome-wide association studies for exposure windows and preterm birth.
Identified 23 metabolic pathways associated with prenatal heat exposure and preterm birth.
Four overlapping metabolites were found: methionine, proline, citrulline, and pipecolate.
These metabolites are linked to amino acid metabolism and oxidative stress regulation.

Cite This Study

Taibl et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ffc0ce034ddc34f595 https://doi.org/10.1126/sciadv.adw8328

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Implication

Prospective analysis identified metabolic pathways related to heat exposure and preterm birth, implying environmental risks may alter biological processes.

Critical windows of prenatal heat exposure and preterm birth: Metabolomic study in the Atlanta African American Maternal-Child Cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

Critical windows of prenatal heat exposure and preterm birth: Metabolomic study in the Atlanta African American Maternal-Child Cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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