Pharmacological activation of TREK-1 improves intraocular pressure in corticosteroid-induced ocular hypertension, indicating potential treatment strategies.
Ocular overexposure to corticosteroids may compromise IOP homeostasis by impairing TM expression and function of TREK-1. Pharmacological activation of TREK-1 facilitates conventional outflow and could help lower IOP in eyes with steroid-induced ocular hypertension.
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Redmon et al. (2025) studied this question.
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