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November 21, 2025PathogensOpen Access

Genomic Evidence for the Rise of Salmonella Typhimurium ST34 with Increased Plasmid-Mediated Resistance in the Thailand Pork Chain

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Authors

HLHongmei LiuNWNing WangSASunpetch Angkititrakul

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Overview

Genomic analysis finds multi-drug resistant Salmonella Typhimurium ST34 in Thailand's pork, suggesting public health risks from plasmid-mediated resistance.

Key Points

  • To characterize the genomic features of multi-drug resistant Salmonella Typhimurium ST34 in the Thailand pork supply chain.
  • Collected 25 Salmonella Typhimurium isolates from pig carcasses and pork swabs in northeastern Thailand.
  • Conducted whole-genome sequencing on nine representative isolates across three seasons.
  • Analyzed sequenced genomes for phylogenetic relationships and antimicrobial resistance determinants.
  • Identified ST34 as the predominant sequence type (77.8%) among Salmonella Typhimurium isolates.
  • ST34 isolates carried diverse antimicrobial resistance genes on plasmids, including tetracycline and sulfonamide resistance.
  • Phylogenetic analysis revealed high core genome conservation over 90% with variability in genomic islands.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ffc0ce034ddc34f68dhttps://doi.org/10.3390/pathogens14121190
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