PLOS Biology demonstrates logic-gated activity of nanobody-drug conjugates, improving G protein-coupled receptor signaling.
Bitopic ligands that engage two distinct binding sites offer exciting opportunities for finely tuned control of G protein-coupled receptor signaling. A recent study in PLOS Biology employed click chemistry to generate novel nanobody-small molecule conjugates and demonstrated their logic-gated activity at co-expressed receptor pairs with improved signaling profiles.
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Huang et al. (2025) studied this question.
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