What question did this study set out to answer?

This study aims to evaluate the effects of splenectomy on postoperative morbidity and survival in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

November 20, 2025Journal of Clinical MedicineOpen Access

The Effect of Splenectomy on Postoperative Morbidity and Survival in Patients with Peritoneal Carcinomatosis

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Authors

SASerkan Ademoğlu İAİsa Caner Aydın ASAhmet Orhan Sunar

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Implication

Retrospective analysis highlights splenectomy increases hospitalization without affecting survival outcomes among patients with peritoneal carcinomatosis, suggesting potential prognostic differences.

Key Points

This study aims to evaluate the effects of splenectomy on postoperative morbidity and survival in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
Retrospective analysis of 149 patients who underwent CRS + HIPEC from 2018–2022.
Categorization of patients by splenectomy with stratification by surgical indications.
Assessment of demographic characteristics, complications, and survival outcomes.
Splenectomy was linked with longer ICU stay (median 1.5 vs. 1 day) and increased hospitalization (median 12 vs. 9 days).
No significant impact on overall survival (OS) or disease-free survival (DFS) when not stratified by indication.
For splenectomy related to peritoneal implants, worse DFS was predicted, while hilar invasion-related splenectomy showed protective effects.

Cite This Study

Ademoğlu et al. (2025) studied this question.

synapsesocial.com/papers/6924e405c0ce034ddc34f92e https://doi.org/10.3390/jcm14228223

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Implication

Retrospective analysis highlights splenectomy increases hospitalization without affecting survival outcomes among patients with peritoneal carcinomatosis, suggesting potential prognostic differences.

The Effect of Splenectomy on Postoperative Morbidity and Survival in Patients with Peritoneal Carcinomatosis

Discussion

Member takes

Implication

Key Points

Cite This Study

The Effect of Splenectomy on Postoperative Morbidity and Survival in Patients with Peritoneal Carcinomatosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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