Critical Analysis of the AUA 2020/2025 Microscopic Hematuria Guidelines to Predict Urothelial But Not Renal Cortical Neoplasms and Validation of the Individual Clinical Components in Risk Stratification for Urothelial Neoplasms But Not Renal Cortical Neoplasms.

The AUA 2025 guidelines effectively stratify patients with MH into risk groups for urothelial cancer but not renal cortical neoplasms of any kind. Furthermore, the variables utilized in the construction of this model were also validated for urothelial cancers but not renal neoplasms. In this study women over 70 have an incidence of urothelial cancer of 2.2% suggesting females over 70 should be considered high risk. The lack of predictive value for renal cortical neoplasms suggests areas for guideline realignment, specifically the type and goal of renal imaging.