Population Pharmacokinetics of Propofol in Critically Ill Patients with and Without Extracorporeal Membrane Oxygenation

Stéphane Bertin; David Haefliger; Thomas Mercier; Laurent A. Décosterd; Raphaël Giraud; Benjamin Assouline; Antoine Schneider; Thierry Buclin; Monia Guidi; Françoise Livio

doi:10.1007/s40262-025-01585-2

November 20, 2025Clinical PharmacokineticsOpen Access

Population Pharmacokinetics of Propofol in Critically Ill Patients with and Without Extracorporeal Membrane Oxygenation

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Key Points

Propofol pharmacokinetics does not differ between critical care patients with and without ECMO support, indicating similar dosing may be effective.
In this population pharmacokinetics study, significant variability in propofol distribution was confirmed, suggesting individualized dosing may be needed.
Assessment using population pharmacokinetics revealed that propofol metabolism remains consistent across critical illness despite ECMO use.
These findings highlight the need for careful consideration of propofol dosing strategies in critically ill patients undergoing ECMO.

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Implication

Population pharmacokinetics analysis shows high variability of propofol in critically ill patients, implying ECMO does not affect its metabolism.

Abstract

Our popPK analysis shows that propofol PK does not differ between critically ill patients with and without ECMO and confirms a high PK variability in this population.

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Cite This Study

Bertin et al. (2025) studied this question.

synapsesocial.com/papers/6924f074c0ce034ddc34fab7 https://doi.org/10.1007/s40262-025-01585-2

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Population Pharmacokinetics of Propofol in Critically Ill Patients with and Without Extracorporeal Membrane Oxygenation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Population Pharmacokinetics of Propofol in Critically Ill Patients with and Without Extracorporeal Membrane Oxygenation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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