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Characterize alveolar epithelial cells type II and their relationship with surfactant during lung development.

November 20, 2025PLoS ONEOpen Access

Characterization of alveolar epithelial cells type II during postnatal lung development in relation to alveolarization – Stereological studies of rat lungs

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Stereological studies uncover relationships between surfactant and lung volume in rat alveoli during development.

Characterize alveolar epithelial cells type II and their relationship with surfactant during lung development.
Inflated rat lungs at 3, 7, 14, 21 and 90 days old for analysis.
Used light and electron microscopy to examine structural characteristics.
Implemented stereological parameters to quantify alveolar epithelial cells type II.
Significant increase in number of AEII at day 21 of development.
AEII number correlated significantly with alveolar surface and lung volume.
Total lamellar body volume increased at the end of bulk alveolarization.

Hüttmann et al. (2025) studied this question.

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